Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing. Twist2. Gene. twist2. Organism. Danio rerio (Zebrafish) (Brachydanio rerio) Status. UniProt is an ELIXIR core data resource. Main funding by: National Institutes of Health The European Molecular Biology Laboratory State Secretariat for Education, Research and Innovation SERI TWIST2 protein. Gene. TWIST2. Organism. Bos taurus (Bovine) Status. Unreviewed-Annotation score: -Experimental UniProt Consortium European Bioinformatics Institute Protein Information Resource SIB Swiss Institute of Bioinformatics. UniProt is an ELIXIR core data resource TWIST2, twist family bHLH transcription factor 2 Vertebrate Orthologs 3 Vertebrate Orthology Source. Alliance of Genome Resources. Human Ortholog TWIST2, twist UniProt. 2 Sequences. Protein Ontology. PR:000016847 twist-related protein 2 (term hierarchy) InterPro Domains Twist2 is the key Twist isoform coupling aberrant signals from pithelial-mesenchymal transition (EMT) to senescence and is an important candidate biomarker for cervical cancer prognosis. nuclear beta-catenin is accumulated in Twist2-induced EMT cells to facilitates ovarian cancer invasion and metastasis
13345 Ensembl ENSG00000233608 ENSG00000288335 ENSMUSG00000007805 UniProt Q8WVJ9 Q9D030 RefSeq (mRNA) NM_001271893 NM_057179 NM_007855 RefSeq (protein) NP_001258822 NP_476527 NP_031881 Location (UCSC) Chr 2: 238.85 - 238.91 Mb Chr 1: 91.8 - 91.85 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Twist-related protein 2 is a protein that in humans is encoded by the TWIST2 gene. The. TWIST2 (bHLHa39, Dermo-1, DERMO1) Tissue specificityi. The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected UniProt: Q8WVJ9 TWIST2 Research Area Cancer; Cancer; Cancer Metabolism; DATA IMAGES. GTX50850 WB Image WB analysis of extracts from A549, HeLa, and 3T3 cells using GTX50850 Twist2 antibody. REFERENCE. There are currently no references for Twist2 antibody. TWIST2 gene product. bHLHa39, Dermo-1, DERMO1. The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers Full length of human TWIST2. Protein Names. Twist-related protein 2, Class A basic helix-loop-helix protein 39, Dermis-expressed protein 1, TWST2_HUMAN. UniProt Code History. Q3SYL6, Q8WVJ9. Gene Synonyms. TWIST2, BHLHA39, DERMO1, AMS, FFDD3, BBRSAY, SETLSS. Supplier also known as. USBi
Invitrogen Anti-TWIST2 Polyclonal, Catalog # PA5-66539. Tested in Immunocytochemistry (ICC/IF) applications. This antibody reacts with Human samples. Supplied as 100 µL purified antibody (0.3 mg/mL) Anti-Twist2 Antibody. See all Twist-2 products. SKU/Catalog Number. A04422. Size. 100μl. Form. Liquid. Description. Boster Bio Anti-Twist2 Antibody catalog # A04422. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. Storage & Handling. Store at -20°C for one year. For short term storage and frequent use, store at 4°C. Western Blot: Twist-2 Antibody [H00117581-D01P] - Analysis of TWIST2 expression in transfected 293T cell line by TWIST2 polyclonal antibody.Lane 1: TWIST2 transfected lysate (18.10 KDa).Lane 2: Non-transfected lysate. Immunocytochemistry/ Immunofluorescence: Twist-2 Antibody [H00117581-D01P] - Analysis of antibody to TWIST2 on HeLa cell 22160 Ensembl ENSG00000122691 ENSMUSG00000035799 UniProt Q15672 P26687 RefSeq (mRNA) NM_000474 NM_011658 RefSeq (protein) NP_000465 NP_035788 Location (UCSC) Chr 7: 19.02 - 19.12 Mb Chr 12: 33.96 - 33.96 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Twist-related protein 1 (TWIST1) also known as class A basic helix-loop-helix protein 38 (bHLHa38) is a basic helix-loop-helix. . View PDF In Scientific Reports on 2 November 2020 by Lehman, H. L., Kidacki, M., et al.
Tissue i. The Tissue Atlas contains information regarding the expression profiles of human genes both on the mRNA and protein level. The protein expression data from 44 normal human tissue types is derived from antibody-based protein profiling using immunohistochemistry. The green piechart indicates the level of reliability of the analyzed. Immunofluorescent analysis of TWIST2 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and TWIST2 polyclonal antibody (Product # PA5-99393) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa. Anti-TWIST2 antibody produced in rabbit purified immunoglobulin, buffered aqueous solution; Synonyms: DERMO1,MGC117334,bHLHa39; find Sigma-Aldrich-SAB1401972 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldric
Abnova Anti-TWIST2 Monoclonal (3C8), Catalog # H00117581-M01. Tested in Western Blot (WB), Immunohistochemistry (Paraffin) (IHC (P)) and ELISA (ELISA) applications. This antibody reacts with Human samples. Supplied as 100 µg purified antibody (See Label) Tukel et al. (2010) analyzed Twist2 knockout mice on a 129/C57 mixed background and observed a facial phenotype similar to that of Setleis syndrome patients, including thin skin and sparse hair with bilateral pronounced alopecic areas between the ears and the eyes, resembling the bitemporal forceps marks in humans. They also had absent lower eyelashes, narrow snouts, protruding chins, short. Immunohistochemistry-Paraffin: Twist-2 Antibody (3C8) [H00117581-M01] - Analysis of monoclonal antibody to TWIST2 on formalin-fixed paraffin-embedded human adrenal gland. Antibody concentration 3 ug/ml. ELISA: Twist-2 Antibody (3C8) [H00117581-M01] - Detection limit for recombinant GST tagged TWIST2 is 0.3 ng/ml as a capture antibody
Twist1/Twist2 encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development TWIST2 Antibody (CF805382) in WB. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TWIST2 (RC205006, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-TWIST
BioGRID ORCS is an open database of CRISPR screens compiled through comprehensive curation efforts TWIST2 antibody LS-C416907 is an unconjugated rabbit polyclonal antibody to TWIST2 from human. It is reactive with human, mouse and rat. Validated for WB Main Text. Gorlin-Chaudhry-Moss syndrome (GCMS [MIM: 233500]) is a rare condition with a distinctive facial gestalt due to coronal craniosynostosis, maxillary hypoplasia, and microphthalmia leading to narrow palpebral fissures. 1 Other core features include coarse scalp hair and generalized hypertrichosis, severe hypermetropia, short stature, short distal phalanges, dental anomalies, and.
fnab09119 Rabbit Human Mouse ELISA WB twist homolog 2 BHLHa39, Dermis expressed protein 1, Dermo 1, DERMO1, twist homolog 2(Drosophila), Twist related protein 2, TWIST2 Q8WVJ IHC-plus™ TWIST2 Antibody LS-B4547 is a pathologist validated IHC antibody Mouse anti-Human TWIST2. Validated for ELISA,IHC,WB. Tested on 20 paraffin-embedded human tissues UniProt Match RefSeq Flags; TWIST2-001: ENST00000448943.2: 1176: 160aa: ENSP00000405176.2 . Gene/transcipt that contains an open reading frame (ORF). Protein coding. CCDS46558: Q8WVJ9: NM_001271893 NM_057179 NP_001258822 NP_476527: The GENCODE set is the gene set for human and mouse Cell type atlas. Showing single cell type specific RNA data of TWIST2 (bHLHa39, Dermo-1, DERMO1)
Purified recombinant protein of Mouse twist basic helix-loop-helix transcription factor 2 (Twist2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20u Immunocytochemistry - Anti-Twist antibody [Twist2C1a] (ab50887) 4% paraformaldehyde-fixed, 0.1% Triton-permeabilized HeLa (Human epithelial cell line from cervix adenocarcinoma) cells stained for Twist using ab50887 at 100 µg/ml in immunocytochemistry. Western blot - Anti-Twist antibody [Twist2C1a] - ChIP Grade (ab50887) This image is courtesy. Specificity The antibody detects endogenous level of total Twist2 protein. Immunogen Type Peptide-KLH; Immunogen Description Peptide sequence around aa.26~30(P-K-R-F-G) derived from Human Twist2. Target Name Twist2 ; Alternative Names DERMO1; MGC117334; bHLHa39; Uniprot Q8WVJ9; Gene ID 117581; Accession No. Swiss-Prot: Q8WVJ9 NCBI Protein: NP.
TWIST2 (англ. Twist family bHLH transcription factor 2) - білок, який кодується однойменним геном, розташованим у людей на короткому плечі 2-ї хромосоми. Довжина поліпептидного ланцюга білка становить 160 амінокислот, а молекулярна маса — 18. Twist family bHLH transcription factor 2 (TWIST2) is part of the basic helix-loop-helix protein (bHLH) family. It acts as a molecular switch by activating or repressing target genes. The TWIST2 gene is localized on human chromosome 2q37.3. Immunogen TWIST2 (AAH33168, 1 a.a. ~ 160 a.a) full-length recombinant protein with GST tag Monoclonal Anti-TWIST2 antibody produced in mouse clone 3C12, purified immunoglobulin, buffered aqueous solution; Synonyms: DERMO1,MGC117334,bHLHa39; find Sigma-Aldrich-SAB1408856 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldric Recombinant protein of human twist homolog 2 (Drosophila) (TWIST2) Species: Human: Expression Host: HEK293T: Expression cDNA Clone or AA Sequence: Recombinant protein was produced with TrueORF clone, RC205006. Click on the TrueORF clone link to view cDNA and protein sequences. Tag: C-Myc/DDK: Predicted MW: 17.9 kDa: Concentratio Toggle Nav. My Cart Checkout. +44 (0)1223 859 353 firstname.lastname@example.org
Twist2 : twist basic helix-loop-helix transcription factor 2 : Nomenclature updated to reflect human and mouse nomenclature: 1299863: APPROVED: 2013-01-02: Twist2 : twist basic helix-loop-helix transcription factor 2 : Twist2 : twist homolog 2 (Drosophila) Nomenclature updated to reflect human and mouse nomenclature: 1299863: APPROVED: 2004-09. Fusion gene TWIST2--ZHX2 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low probability. UniProt Q15672 - TWST1_HUMAN. Gene TWIST1 Modification Unmodified View Product On Supplier's Website Request a Quote from Abcam. Supplier suggested. Validations. None available. Applications. Chromatin immunoprecipitation (ChIP) Dot blot ; Immunocytochemistry (ICC) Immunocytochemistry-immunoflourescence (ICC-IF TWIST2_ENST00000448943 - Explore an overview of TWIST2_ENST00000448943, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data . Validated for ELISA, IHC and WB
HDAC4 (Histone Deacetylase 4) is a Protein Coding gene. Diseases associated with HDAC4 include Chromosome 2Q37 Deletion Syndrome and Brachydactyly.Among its related pathways are p53 Signaling and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and. 117581 (TWIST2) 09180 Brite Hierarchies 09182 Protein families: genetic information processing 03000 Transcription factors [BR:hsa03000] 117581 (TWIST2) Transcription factors [BR:hsa03000] Eukaryotic type Basic helix-loop-helix (bHLH) Tal/Twist/Atonal/Hen, Mesodermal Twist-like factors 117581 (TWIST2 Fusion gene TWIST2--FAM156A is not found in a RNA-seq dataset of 18 types of cancers from 600 tumor samples (B. Alaei-Mahabadia et al., Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers, PNAS, Nov. 2016
Twist-2 products available through Novus Biologicals. Browse our Twist-2 product catalog backed by our Guarantee+ 470692 (TWIST2) 09180 Brite Hierarchies 09182 Protein families: genetic information processing 03000 Transcription factors [BR:ptr03000] 470692 (TWIST2) Transcription factors [BR:ptr03000] Eukaryotic type Basic helix-loop-helix (bHLH) Tal/Twist/Atonal/Hen, Mesodermal Twist-like factors 470692 (TWIST2 The world's first wiki where authorship really matters. Due credit and reputation for authors [authorship tracking technology]. Imagine a global collaborative knowledge base for original thoughts [Nature Genetics]
Το twist2 είναι βασικός παράγοντας μεταγραφής έλικα-βρόχου-έλικα που συνδέεται με μοτίβα αλληλουχιών του dna e-box (5'-canntg-3 ') ως ετεροδιμερές και αναστέλλει την μεταγραφική ενεργοποίηση these targets were united by UniProt database.Targets of lung cancer were enriched through GeneCards,NCBI(Gene),TherapeuticTarget Database,andDisGeNET(v7.0)databases.Then the intersection targets of TFAE and disease were obtained. The STRING network and the Cytoscape3.7.2wereusedtoconstructProtein-Protein-Interaction(PPI) network,theDAVI JASPAR is an open-access database of curated, non-redundant transcription factor (TF) binding profiles stored as position frequency matrices (PFMs) and TF flexible models (TFFMs) for TFs across multiple species in six taxonomic groups. You are using the latest 8th release (2020) of JASPAR While TWIST1 together with SNAI1 in humans is a recognized enabler of EMT in certain cancer cells , TWIST2 is also responsible for maintaining preosteoblasts in an undifferentiated state . Along with SNAI1, TWIST1 is a known driver of N-Cadherin (CDH2) expression, and we demonstrated in the present study significant downregulation of CDH2.
Fusion gene TWIST2--HDAC4 has not been seen in a healthy sample (RNA-seq data from some samples from 1000 genomes project: Greger et al., Tandem RNA Chimeras Contribute to Transcriptome Diversity in Human Population and Are Associated with Intronic Genetic Variants, Plos One, Aug 2014 ). Therefore this candidate fusion gene has a low. UniProt:Q8WVJ9 TWIST2 1 TWIST2 [nucleoplasm] (R-HSA-445444
. Haploinsufficiency of the transcription factor TWIST1 is associated with Saethre-Chotzen Syndrome and is manifested by craniosynostosis, which is the premature closure of the calvaria sutures
The inheritance of horns, polledness and scurs in cattle has been studied since the early 1900s. Understanding the pattern of inheritance was a challenging task for early researchers owing to the epistatic relationship that POLLED has with other loci, and the subsequent difficulties in inferring the genotype of an individual (reviewed by Prayaga 2007) UniProt ID : Q9PVG4: Products Types Recombinant Protein. TWIST1-2973H: Recombinant Human TWIST1 Protein, MYC/DDK-tagged +Inquiry: Twist1-6740M: Recombinant Mouse Twist1 Protein, Myc/DDK-tagged TWIST1 TWIST2. Datasheet MSDS Download Datasheet.
After identifying a heterozygous mutation in the TWIST2 gene (E75K; 607556.0004) in patients with ablepharon-macrostomia syndrome (AMS; 200110), the features of which closely overlap those of BBRSAY, Marchegiani et al. (2015) analyzed TWIST2 in 12 individuals with BBRSAY and detected heterozygosity for 2 different missense mutations also involving codon 75 in 11 of the patients: 9 patients. Fragment spectra were searched against the Uniprot human reference proteome (version December 2017), with a false discovery rate of 1% on PSM and protein level and at least one unique peptide. TWIST1 and TWIST2 in BAG3-depleted BT-549 r DOX 20 (Figure S3A) and similarly in MDA-MB-468 r 5-FU 2000 cells. Sosic et al. (2003) showed that Twist and Dermo1 , which they called Twist1 and Twist2, respectively, were induced by a cytokine signaling pathway that required the dorsal-related protein Rela , a member of the nuclear factor kappa-B (NFKB; see 164011) family of transcription factors, in mice. Twist1 and Twist2 repressed cytokine gene.
twist-related protein 2).TWIST2 is a basic helix-loop-helix transcription factor that binds to E-box DNA motifs (5'-CANNTG-3 TWIST family of basic helix-loop-helix transcription factors mediate human mesenchymal stem cell growth and commitment.Stem Lee MS, Lowe G, Flanagan S, Kuchler K, Glackin CA (November 2000). Human Dermo-1 has attributes similar to twist in early bone. May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development. The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during. Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity)
Function. Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1 (a.k.a. TWIST2).The strongest expression of this mRNA is in placental tissue; in adults, mesodermally derived tissues express. Twist-related protein 1 (TWIST1) also known as class A basic helix-loop-helix protein 38 (bHLHa38) is a basic helix-loop-helix transcription factor that in humans is encoded by the TWIST1 gene